Hanna Méla first studied at the College of Applied Arts and then at the College of Fine Arts in Budapest. Her master was Gyula Rudnay, who maintained a regular relationship with the painting school in Hódmezővásárhely, and her classmates included Jenő Barcsay and Eszter Mattioni. She worked in several genres of painting and graphics. Her artworks were exhibited and sold at exhibitions in the National Salon, the Art Gallery (Műcsarnok), the Venice Biennale and in Paris as early as the 1920s and 30s. The son of her cousin living in Germany, William Hanna, already born in the United States of America, was a seven-time Oscar-winning cartoon animator and director. After her death, she had exhibitions in Hódmezővásárhely (2005) and Szeged (2006).
Hanna Mela's artworks are brightly colored works with a rich choice of themes. Her oeuvre includetable pictures, biblical and chivalric themes, city and village life pictures, clothing history pictures, portraits, caricatures, and landscapes.